An Overview of the Transporters for the Neurodrugs Based on the Blood-Brain Barrier

doi:10.3969/j.issn.2095-1396.2016.06. 005

Abstract

Abstract: The drug transporters are membrane transport proteins that are present in all organisms. These transporter proteins control the influx and efflux of endogenous and exogenous components including drugs， resulting in the critical roles in cellular substance homeostasis. The blood-brain barrier （BBB） from the systemic circulation represents a barrier to affect the uptake and output of both endogenous compounds and xenobiotics into or out of brain. Members of the solute carrier and ATP-binding case families are present on these barriers. Differences exist in the localization and expression of these transport proteins on the BBB， resulting in functional differences in the properties of the transport and plasma drug concentrations， effects and toxicities for the neuropsycho-drugs. This review focuses on the research overview of drug transporters based on the BBB with the neuropsycho-diseases.

Key words: blood-brain barrier, transporter, expression regulation, neuropsychodisease

XU Wei-zhe，LI Xiao-rong，XIONG Jie，XU Ping-xiang，XUE Ming. An Overview of the Transporters for the Neurodrugs Based on the Blood-Brain Barrier[J]. Acta Neuropharmacologica, 2016, 6(6): 45-54.

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